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KMID : 0545120100200020346
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 2 p.346 ~ p.349
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Effect of Limited Oxygen Supply on Coenzyme Q10 Production and Its Relation to Limited Electron Transfer and Oxidative Stress in Rhizobium radiobacter T6102
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Seo Myung-Ji
Kim Soon-Ok
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Abstract
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Coenzyme Q10 (CoQ10) productions from Rhizobium radiobacter T6102 were monitored under various oxygen supply conditions by controlling the agitation speeds, aeration rates, and dissolved oxygen levels. As the results, the CoQ10 production was enhanced by limited oxygen supply. To investigate whether the CoQ10 production is associated with its physiological functions of electron carrier and antioxidant, the effects of sodium azide and hydrogen peroxide on the CoQ10 production were studied, showing that the CoQ10 contents were slightly enhanced with increasing sodium azide (up to 0.4 mM) and hydrogen peroxide (up to 10 μM) concentrations. These results suggest the plausible mechanism where the limited electron transfer stimulating the environments of limited oxygen supply and oxidative stress could accumulate the CoQ10, providing the relationship between the CoQ10 physiological functions and its regulation system.
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KEYWORD
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Coenzyme Q10, hydrogen peroxide, limited oxygen supply, Rhizobium radiobacter, sodium azide
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